Author

Yan-Fang Xian

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Review Open access Jul 2026

Multi-Mechanistic Androgen Receptor Suppression by Chinese Medicine: A Polypharmacology Strategy Against Castration-Resistant Prostate Cancer

Castration-resistant prostate cancer (CRPC) is lethal because of persistent androgen receptor (AR) signaling, even when patients undergo androgen deprivation therapy. Resistance can arise through intratumoral androgen synthesis, AR overexpression, mutations in the ligand-binding domain, constitutively active splice...

Peiyao Ren, Yuanyang Tian, Boda Guo et al. · Integrative Medicine in Neph... · 0 citations

Aug 2026

Oxypalmatine alleviates ulcerative colitis through RAB8A-mediated inhibition of STAT1-driven pro-inflammatory macrophage polarization.

OPAL significantly ameliorated DSS-induced colitis by reducing colon shortening, weight loss and intestinal barrier damage, which relied on the inhibition on M1 polarization as confirmed by flowcytometry and macrophage-depletion.

Zhuo-Wen Huang, Xia Zhang, Yi-Long Fang et al. · Phytomedicine · 0 citations