Author

Yan-Fei Li

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Open access Sep 2026

Deoxynivalenol triggers pyroptosis in intestinal epithelial cells via NLRP3 inflammasome activation mediated by the TLR4-NF-κB/p38 MAPK signaling pathway.

TLR4 inhibition with TLR4-IN-C34 confirmed that TLR4 acts as an upstream regulator controlling both NF-κB and p38 MAPK signaling, thus inhibiting NLRP3 inflammasome activation and alleviating pyroptosis.

Wang-Yong Yu, Ya-Fei Sun, Ming-Yue Wang et al. · Ecotoxicology and Environmen... · 0 citations

Jul 2026

Chronic Kidney Disease Risk Posed by 1-Ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) Benzene (EDPrB): An AOP of mTOR-Mediated Autophagy Dysregulation.

This study demonstrates that exposure to EDPrB can induce inflammatory responses and fibrosis in human renal cortical proximal tubule epithelial cells (HK-2), and proposes an AOP framework focused on EDPrB-induced CKD, highlighting the renal risks of FLCMs and supports stricter environmental release regulations.

Chenjiao Miao, Binwen Zhang, Wang-Yong Yu et al. · Environmental Science and Te... · 0 citations