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Author

Yan-Fei Zhang

2 papers indexed here

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Open access Sep 2026

Vitamin D Pathway Activation Reduces Cardiomyocyte DNA Damage and Improves Cardiac Contractility in Preclinical Models.

BACKGROUND In heart failure (HF), DNA damage caused by various external stressors contributes to cardiac dysfunction through the activation of DNA damage response pathways. To date, no clinical strategies have been established to restore cardiac function by reducing accumulated DNA damage. We previously found that vita...

Masamichi Ito, Manami Katoh, Masayuki Kubota et al. · 0 citations
Open access Sep 2026

SAE1 knockdown attenuates hepatic fibrosis by promoting ubiquitination and proteasomal degradation of TGF-β receptors

Abstract Objective Liver fibrosis is characterised by excessive accumulation of extracellular matrix and can ultimately progress to cirrhosis and malignant transformation. Activation of hepatic stellate cells (HSCs), largely driven by transforming growth factor-beta (TGF-β) signalling, is a central event in fibrogenesi...

Tong Liu, Meng-Ru Wang, Guo-Liang Zheng et al. · 0 citations

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