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Author

Yan-Fu Xia

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Review Open access Aug 2026

Targeting glutathione peroxidase 4 in ferroptosis: from immune regulation to pharmacological development and translational applications

Glutathione peroxidase 4 (GPX4) is a selenocysteine (Sec)-containing antioxidant enzyme and the only known mammalian enzyme capable of directly reducing membrane-embedded phospholipid and cholesterol hydroperoxides. It is recognized as a central regulator of ferroptosis, modulating cellular redox balance and influencin...

Qian-Yue Yang, Yan-Fu Xia, Yong Wu et al. · 0 citations

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