ABSTRACT Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric...
Liang Yan, Si-Yi Liu, Yan-Ling Li et al.· Cancer Medicine· 0 citations
A dual-modal, stepwise-targeting lipid nanoparticle platform that integrates mitochondrial protection with matrix metalloproteinase-12 (MMP-12) silencing to achieve coordinated neurovascular protection in ischemic stroke is reported.
Xu-Rui Gu, Sai Wang, Lei Chen et al.· Journal of Controlled Releas...· 0 citations
This review systematically examines the intricate regulatory network of cellular senescence, encompassing multiple pathways including telomere dysfunction, DNA damage response, epigenetic remodeling, hormone signaling, and metabolic reprogramming, and integrating such strategies with conventional therapies holds promis...
