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Yan-Hua Wen

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Open access Sep 2026

A framework of Microbial Genomic Database for clinical metagenomic pathogen diagnosis: development and multi-cohort evaluation

Clinical metagenomic next-generation sequencing (mNGS) enables broad, untargeted pathogen detection, but its analytical performance depends on host depletion strategy, reference database composition, and alignment methodology. We developed the Clinical Microbial Genomic Database (CMGD), a clinically focused referen...

Han Xia, Yan-Hua Wen, Xu-Ming Li et al. · 0 citations

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