Yan-Hua Yan

Analysis of encoded plasmid poly(dA) length distribution using liquid chromatography-mass spectrometry.

Poly(A) tail plays critical roles in mRNA stability and translation efficiency, enhancing the potential of mRNA in vaccine and therapeutics. Encoded poly(dA) tail provides advantages over enzymatically synthesized tails, including product homogeneity, higher reproducibility, and reduced manufacturing costs. However, in...