Author

Yan-Jiang Wang

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Open access Aug 2026

The Global, Regional, and National Burden of Young‐Onset Dementia: An Updated Analysis of the Global Burden of Disease Study 2021

Young‐onset dementia (YOD), defined as dementia with onset between 40 and 65 years of age, is an emerging global health concern associated with substantial healthcare and socioeconomic burdens. Using data from the Global Burden of Disease Study 2021, this population‐based study analyzed trends in the prevalence, deat...

Yang Zhao, Tai-Yi Sun, Rui Zhang et al. · Brain Health · 0 citations

Oct 2026

Bazedoxifene restores myelin changes and attenuates cognitive deficits in a mouse model of Alzheimer's disease.

BackgroundDemyelination and remyelination are critical processes in the pathogenesis of Alzheimer's disease (AD). The selective estrogen receptor modulator bazedoxifene (BZA) has been shown to promote remyelination, suggesting its potential therapeutic efficacy.ObjectiveThis study aimed to evaluate the therapeutic effi...

Man-Yu Xu, Yu-Di Bai, Xiao-Qin Zeng et al. · Journal of Alzheimer's Disea... · 0 citations

Aug 2026

Cross-Sectional and Longitudinal Diagnostic Performance of Plasma p-tau217 and p-tau217/Aβ42 in Alzheimer's Disease.

OBJECTIVE Recent studies suggest that combining plasma phosphorylated tau (p-tau) with β-amyloid (Aβ) may improve diagnosis accuracy for Alzheimer's disease (AD). However, the cross-sectional and longitudinal concordance of these markers with Aβ positron emission tomography (PET) positivity remains incompletely underst...

Mingxing Jiang, Guo-Yu Lan, Jiayi Zhu et al. · Annals of Neurology · 0 citations