Author

Yan Leng

2 papers indexed here

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Open access Sep 2026

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation

Abstract Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury and is associated with mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and tubular cell apoptosis. Sigma-1 receptor (Sigma1R), an intracellular chaperone, helps maintain mitochondrial homeostasis an...

Si-Yuan Gong, Yong-Hong Xiong, Wen-Yuan Li et al. · Renal Failure · 0 citations

Review Open access Sep 2026

Cardiomyocyte Calcium Homeostasis Remodeling in Diabetes-Related HFpEF: Mechanisms and Therapeutic Perspectives.

More direct approaches, including modulation of Ca2+-handling proteins, ryanodine receptor 2 (RyR2) stabilization, sarcoplasmic reticulum Ca2-ATPase 2a (SERCA2a) restoration, and repair of T-tubule-associated microdomains, remain largely preclinical or early translational.

Ke-Xin Zhang, Jia-Xuan Lan, Yan Leng et al. · Pharmacological Research · 1 citation