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Author

Yan Li

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2 papers indexed here

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Open access Sep 2026

HSP90AA1 Knockdown Enhances Doxorubicin Sensitivity by Promoting Immunogenic Cell Death-Related Signaling and Immune-Related Tumor Microenvironment Remodeling in Breast Cancer

Simple Summary Doxorubicin is an important chemotherapy drug for breast cancer, but treatment resistance and limited antitumor immune responses can reduce its effectiveness. In this study, we investigated HSP90AA1, a stress-related molecular chaperone that may help breast cancer cells adapt to chemotherapy. Using publi...

Rui Chen, Yao Jin, Chang-Bin Xie et al. · 0 citations
Review Open access Sep 2026

Metabolite-driven dysfunction of intratumoral tertiary lymphoid structures: single-cell and spatial omics perspectives on cancer immune escape

This work proposes that metabolite-driven remodeling of the tumor microenvironment is a major cause of intratumoral TLS failure and outlines biomarker-guided strategies to restore TLS competence, including inhibition of tumor-derived tryptophan metabolism to promote TLS maturation and enhance anti-PD-1 efficacy.

Yi-Feng Wang, Yan Li, Shu-Juan Wei et al. · 0 citations

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