Sep 2026
Trillin alleviates rheumatoid arthritis by inhibiting TXNIP-mediated mitochondrial damage and NLRP3-dependent pyroptosis.
Macrophage pyroptosis in the synovial tissue of patients with rheumatoid arthritis (RA) releases large amounts of inflammatory cytokines, which further exacerbate the pathological progression of RA. Trillin, a natural steroidal saponin in Trillium tschonoskii Maxim and other medicinal plants, exhibits potent antioxidan...
Jing-Jing He, Xin-Ying Wang, Xiao-Di Lian et al.
· Biochemical Pharmacology · 0 citations