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Open access Sep 2026

Shewanella oneidensis employs both β-lactam resistance and tolerance controlled by the PghKR system

ABSTRACT Antibiotic tolerance enables bacterial survival during antibiotic exposure and can promote the evolution of resistance, thereby threatening therapeutic efficacy. However, the molecular mechanisms underlying tolerance and its relationship with resistance remain incompletely understood. In this study, we show th...

Jing-Xiao Cai, Yan Liang, Yu Chen et al. · 0 citations
Sep 2026

CDK4/6 Inhibitor Abemaciclib Arrests and Reverses Kidney Cyst Progression in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.

BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder leading to kidney failure. Tolvaptan, the only FDA-approved therapy, modestly slows disease progression but is limited by significant adverse effects, highlighting the need for more effective and better-tolerated treat...

Ying-Shu Cao, Xiao-Bo Sun, Yan Huang et al. · 0 citations

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