Aug 2026
Conformational Features of Aβ25-35 and Its Mutants Suggest Toxic Structural Determinants: Insights from REST2 Simulations.
It is proposed that the disassembly propensity of dominant β-barrels governs their transition from off-pathway states to cytotoxic oligomers, and N-terminal domain exposure in on-pathway intermediates modulates peptide-membrane interactions.
Y. Mo, Yong-Hui Hou, Rui Su et al.
· Journal of Physical Chemistr... · 0 citations