Yan-Mei Dou

Mitochondrial DNA mutation triggers early-onset intestinal epithelial cell dysfunction during acute colitis

Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial cells (IECs) remain poorly understood. Here, we employed...