Open access
Aug 2026
A computational framework integrating a protein language model with alchemical simulation for gain-of-function enzyme design.
The ESM-FEP framework establishes a generalizable and efficient strategy for the rational design of gain-of-function enzymes, with broad applications in biocatalysis, bioremediation, and precision agriculture.
Long-Can Mei, Jian Wu, Li-Jun Chen et al.
· Plant Communications · 0 citations