Open access
Oct 2026
ATF4 alleviates doxorubicin-induced cardiomyopathy by promoting H2S production and antioxidant defense.
Doxorubicin (DOX) remains a cornerstone in cancer treatment. However, its clinical utilization is significantly hampered by dose-dependent cardiotoxicity. The generation of reactive oxygen species (ROS) constitutes the central component of the pathogenesis of DOX-induced cardiotoxicity. Activating transcription factor...
Shu-Ting Xu, Yan Shi, Xiao-Shuai Zhao et al.
· Biochemical and Biophysical... · 0 citations