Author

Yan Wang

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Oct 2026

10-Gingerol attenuates alcohol-induced colon injury by modulating IL-36R and downstream cGAS-STING signaling to suppress macrophage inflammation and ferroptosis.

ETHNOPHARMACOLOGICAL RELEVANCE Ginger (Zingiber officinale Roscoe, Zingiberaceae) is traditionally used in Chinese and Ayurvedic/Tibb-Unani medicine for gastrointestinal and inflammatory disorders. Its bioactive constituent 10-gingerol (10-G) exhibits intestinal anti-inflammatory activity, providing a rationale for inv...

Miao Li, Tian-Tian Wang, Yan-Ni Huang et al. · Journal of Ethnopharmacology · 0 citations

Open access Aug 2026

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

These findings identify AR/ZNF217/PROM2 signaling as a central determinant of ferroptotic vulnerability in prostate cancer and suggest that targeting this pathway may enhance sensitivity to AR inhibition, providing a molecular rationale for combination therapy in castration-resistant prostate cancer.

Wenjun Hao, Peng Liang, Wanglong Zheng et al. · Oncogenesis · 0 citations