Author

Yan Xiong

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Open access Oct 2026

An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.

MYC amplification is common and often extrachromosomal (ecDNA) in cancer. To define how MYC DNA copy gains arise from diploid genomes, we assessed whether epigenetic enzymes directly control focal MYC over-replication and amplification. We demonstrate that H3K4 methylation primes MYC for amplification by the H3K9/K36 t...

Benjamin Ferman, Chloe Azadegan, John Santoro et al. · Molecules and Cells · 0 citations

Open access Sep 2026

dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels

Precise and rapid control over cellular protein levels is essential to dissect complex biological systems. Chemical genetic approaches such as dTAG, in which a target is fused to a degron tag (FKBP12F36V) and degraded upon small molecule-mediated recruitment of E3 ligases, have enabled rapid and tunable control over pr...

Sunil Guharajan, Xiang-Yang Song, S. Sengupta et al. · bioRxiv · 0 citations

Open access Aug 2026

Expanding the Ligandable Chemical Space of OTUB1 through Discovery of a Four-Membered-Ring Recruiter Chemotype

Deubiquitinase-targeting chimeras (DUBTACs) have emerged as a promising strategy for targeted protein stabilization, but their broader application remains limited by the scarcity of ligandable deubiquitinase recruiters. Here, we report a previously unexplored four-membered-ring OTUB1 recruiter chemotype. Through system...

Qiong Wu, Xiang-Yang Song, Li Chen et al. · bioRxiv · 0 citations