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Yan-Xuan Wu

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Review Open access Sep 2026

Neuroimmune crosstalk in osteoarthritis pain: from synovial inflammation to pain sensitization

Pain in osteoarthritis (OA) is not explained adequately by cartilage loss or radiographic severity. Synovial inflammation, tissue damage, and neural plasticity interact across the joint, dorsal root ganglia, spinal cord, and brain to shape the intensity and persistence of symptoms. This mini review examines the synoviu...

Zhong-Yan Mao, Kang Wang, Yan-Xuan Wu et al. · 0 citations
Open access Aug 2026

Metabolic Engineering of Komagataella Phaffii for de Novo Synthesis of Retinol From Methanol

Retinol, a derivative of vitamin A with potent antioxidant and therapeutic properties, is in high market demand. In response to the low productivity of conventional methods, metabolic engineering has been explored for microbial retinol production. However, systematic engineering strategies for high‐level retinol synthe...

Yan-Xuan Wu, Chen-Guang Liu, Shu-Li Liang et al. · 0 citations
Aug 2026

Reprogramming Komagataella phaffii Cell Factory for High-Yield Production of 3S,3′S-Astaxanthin via Multiplex Metabolic Engineering and Its Application

The synthesis of 3S,3′S-astaxanthin was successfully and effectively applied in shrimp farming for color enhancement and antioxidant effects and will pave the way for astaxanthin industrial production.

Xinying Zhang, Ji-Yuan Hu, Yan-Xuan Wu et al. · 0 citations

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