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Author

Yan-Yan Chang

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Open access Sep 2026

A859L Plays a Critical Role in Facilitating Efficient African Swine Fever Virus Replication

African swine fever virus (ASFV) is a highly pathogenic agent that poses a severe threat to the global swine industry. The biological function of A859L, an ASFV-encoded RNA helicase, remains largely elusive. Here, we show that A859L is highly conserved across diverse ASFV isolates and belongs to the SF2 superfamily of...

Xiang-Tao Zhu, Hong-Yu Yan, Wan-Hui Zhou et al. · 0 citations
Open access Jan 2026

IRES Mutation Confers a Replicative Advantage to SVA by Enhancing Translation Efficiency

This study aimed to characterize the mutational and evolutionary patterns of the SVA genome during its transmission within host cells exhibiting enhanced innate immunity, and indicated that the mutant virus was unable to evade host antiviral innate immunity, whereas it significantly enhanced the translational activity...

Tao Li, Wen Dang, Wei-Wei Li et al. · 0 citations

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