Yan-Yu Zhang

UBA1 as a proteostasis-innate immunity checkpoint: lessons from vexas syndrome and therapeutic implications

Ubiquitin-like modifier activating enzyme 1 (UBA1) occupies the apex of the canonical ubiquitination cascade and supplies activated ubiquitin to a broad network of E2 conjugating enzymes and E3 ligases. Although traditionally regarded as an essential housekeeping enzyme, human genetics has revealed a more instructive f...