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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yan Zhao

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2 papers indexed here

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Sep 2026

A Click-Triggered Bioorthogonal Strategy for Dual Activation of Covalent Warheads and Reporter Payloads

Michael acceptors are indispensable electrophilic motifs in chemical biology and covalent drug discovery, yet their intrinsic “always-on” reactivity frequently causes off-target modification and limits therapeutic precision. Here we report a bioorthogonal strategy for externally controlling Michael acceptor reactivit...

Xiao-Wei Xu, Yang-Fei Shi, Yan Zhao et al. · 0 citations
Oct 2026

Lysozyme-Associated Quercetin-Manganese Nanocomposites for Kidney-Targeted Antiferroptotic Therapy of Acute Kidney Injury.

Acute kidney injury (AKI) is a life-threatening syndrome in which oxidative stress, ferroptosis, and inflammatory amplification converge to damage renal proximal tubular epithelial cells. Although antioxidant and antiferroptotic therapies are conceptually attractive, their efficacy is restricted by rapid clearance and...

Yan-Zhu Sun, Hao-Lin Zhang, Heng-Zhi Liu et al. · 0 citations

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