Yan-Zhu Liu

A hypoxia/necrosis-driven metabolic-epigenetic axis H3K9 lactylation-mediated SKP2 signaling promotes glioblastoma progression

Tumor hypoxia/necrosis as a hallmark of glioblastoma (GBM) is strongly associated with malignant progression and poor prognosis of GBM, however, its roles and mechanisms in the behaviors of neighboring surviving GBM cells remain poorly understood. Here, we analyzed public transcriptomic datasets to characterize gene...