Author

Yan Zhuang

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Open access Oct 2026

Targeting macrophage-derived oncostatin M preserves cardiomyocyte mitochondrial bioenergetics and contractile function in fulminant myocarditis.

BACKGROUND Fulminant myocarditis (FM) is an acute inflammatory cardiomyopathy with high risk of cardiogenic shock. Current management relies largely on circulatory support, while mechanism-based pharmacological targets remain poorly defined. METHODS Cardiac CD45+ single-cell RNA sequencing, whole-heart single-nucleus...

Yong-Cui Yan, Ze-Yu Sun, Yi He et al. · Pharmacological Research · 0 citations

Open access Aug 2026

Impact of social isolation and loneliness on the risk of functional bowel disorders: findings from a large-scale cohort study

Background Social isolation and loneliness are recognised as important risk factors for various health outcomes. However, their impact on functional bowel disorders (FBDs) remains underexplored. Aims To explore the associations of social isolation and loneliness with the risk of FBDs in a large prospective cohort. Meth...

Yan Ran, Jian Lei, Lian-Li Wang et al. · BJPsych Open · 0 citations