Ya'nan Hu

Combined treatment of spinal cord injury using channeled Porous-GelMA scaffold loaded with genetically engineered MSCs expressing inducible ChABC and constitutive BDNF

In vivo studies showed that the BDNF/ChABC-MSCs–CPGS integrated system significantly improved BBB scores, markedly reduced lesion size and collagen deposition, and increased expression of the axonal regeneration markers, NF-H and GAP43, thereby promoting axonal regeneration and functional recovery.