Author

Yang Li

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Open access Sep 2026

TRIM21-mediated degradation and ubiquitination of ANXA2 facilitates esophageal squamous cell carcinoma radiosensitivity through attenuating the Beclin1-dependent autophagy.

Radiotherapy is a key component of the standard treatment for esophageal squamous cell carcinoma (ESCC); however, therapeutic efficacy is frequently limited by resistance. Elucidating the mechanisms governing radiosensitivity may facilitate the development of improved therapeutic strategies for patients with ESCC. In t...

D. Guo, Jin-Di Wang, Jin-Feng Liu et al. · Biomedicine & pharmacotherap... · 0 citations

Open access Aug 2026

Network pharmacology-guided identification of Rabdosia rubescent as a suppressor of laryngeal cancer via MMP9-mediated extracellular matrix remodeling: integrated in silico and experimental validation

By effectively targeting the MMP9 pathway, Cirsiliol suppresses tumor invasiveness and migration, highlighting its potential as a promising lead compound for the treatment of laryngeal cancer.

Xue-Feng Wang, Guan-Ying Ren, Yong-Gang Zhang et al. · Frontiers in Pharmacology · 0 citations