Author

Yang Liu

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Open access Aug 2026

Microglia-targeted Panax notoginseng polysaccharide nanoparticles alleviate Alzheimer's disease via AMPK-mTOR/HIF-1α-mediated immunometabolic reprogramming

Alzheimer's disease (AD) is increasingly recognized as an immunometabolic disorder characterized by a self-reinforcing cycle of neuroinflammation and glycolytic reprogramming in microglia. Herein, we developed KPBIT@NPs, a microglia-targeted polysaccharide-based nanomedicine. Unlike many conventional nanocarriers that...

Ge Zhang, Liang Kong, Ruihan Guo et al. · Materials Today Bio · 0 citations

Sep 2026

Stepwise progressive dual-regulated micelles enhance the therapeutic efficacy of hepatocellular carcinoma by remodeling the tumor microenvironment.

This system provides a multifunctional traditional Chinese medicine (TCM) nanodelivery strategy for HCC therapy and exhibits sequential synergistic effects combining GRh2-mediated TME remodeling and Ten H-mediated tumor cell elimination.

Mu-Han Chen, Tian-Hua Li, De-Jin Ma et al. · Biomaterials Advances · 0 citations

Open access Sep 2026

Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer’s disease models

Introduction Icariside II (ICS II), a major bioactive flavonoid metabolite from Epimedium, has been reported to exert neuroprotective effects, but its role in regulating mitochondrial dysfunction-related neuronal injury in Alzheimer’s disease (AD) has not been fully clarified. Methods In this study, we administered ICS...

Si-Yu Shan, Jia-Ming Bai, Yu Tian et al. · Frontiers in Pharmacology · 0 citations