FPGS drives breast cancer proliferation via CDK9-mediated mitophagy through the mTOR signaling pathway.
Breast cancer remains the leading cause of cancer death among women worldwide, and metabolic reprogramming is increasingly recognized as a hallmark of this disease. Folylpolyglutamate Synthase (FPGS), a key enzyme in folate metabolism, catalyzes the polyglutamylation that retains folate inside cells; however, its role...