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Open access Sep 2026

Phenotypic heterogeneity and genetic mechanisms of phage resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae

ABSTRACT Phage resistance represents a major obstacle to the clinical application of phage therapy for multidrug-resistant bacterial pathogens. A comprehensive understanding of the phenotypic heterogeneity and molecular mechanisms underlying phage resistance is critical for deciphering bacterium-phage interactions and...

Ye Huang, Yi-Chen Liu, Shi-Min Chen et al. · 0 citations
Open access Aug 2026

From low- to high-level resistance: dynamic transcriptional adaptations and efflux pump amplification in cefiderocol-stressed Pseudomonas aeruginosa

Pseudomonas aeruginosa is a bacterium with high antimicrobial resistance to several drugs including carbapenems. Recently, resistance to cefiderocol (FDC), a new siderophore cephalosporin, has been reported despite its rare use in clinical practice. Therefore, this study aimed to investigate the dynamics of different r...

Ting Zhang, Han-Xu Hong, Jun Wang et al. · 0 citations

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