Author

Yang Pan

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Review Open access Sep 2026

Gut microbiota-derived metabolites and host interactions in fibrotic diseases: mechanisms, cross-organ signatures, and therapeutic opportunities

Fibrosis is a common end-stage pathological change across multiple chronic organ injuries and a primary driver of global organ failure and high mortality. Accumulating evidence indicates that the gut microbiota and its metabolites can bidirectionally regulate fibrosis progression through the gut–organ axis; however, a...

Yang Pan, Chang Shu, Yu-Qing Mei et al. · Frontiers in Microbiology · 0 citations

Review Open access Oct 2026

KRAS Mutations in Cancers: From Undruggable Dilemma to Precision Medicine

ABSTRACT KRAS is one of the most frequently altered oncogenic drivers across human solid tumors and has long represented a central challenge in precision oncology. The clinical success of covalent KRAS G12C inhibitors has transformed a historically “undruggable” target into a tractable therapeutic class, but durable be...

Jia-Ying Cai, Yi-Min Wu, Xing Jia et al. · MedComm · 0 citations

Open access Sep 2026

Rechallenge With Immunotherapy for ES‐SCLC: Efficacy and Safety From a Retrospective Propensity Score‐Matched Study

Although immunotherapy combined with platinum‐based chemotherapy is now the standard first‐line treatment for extensive‐stage small cell lung cancer (ES‐SCLC), the benefit of continuing immune checkpoint inhibitors (ICIs) after disease progression (PD) remains uncertain. This real‐world study assessed the efficacy and...

Yu-Xia Wang, Yun-Feng Tong, Yang Pan et al. · Cancer Medicine · 0 citations