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Author

Yang Teng

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Open access 2027

Cytotoxic metabolites from the endophytic fungus Aspergillus costaricensis y15

Eleven compounds (1–11), comprising two previously undescribed tetrahydrofuran derivatives (1–2) alongside nine recognized metabolites (3–11), were separated and purified from the EtOAc extract derived from the endophytic strain Aspergillus costaricensis. The structural determination of the compounds was achieved unamb...

Shao-Fei Teng, Kai-Ling Yang, Chen-Chen Sun et al. · 0 citations
Jul 2026

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation.

This work developed FL47, a dual-site ligand that combines extensive noncovalent interactions with targeted covalent engagement that exhibits submicromolar affinity, robust cellular target engagement, and markedly reduced cytotoxicity relative to previously reported covalent recruiters.

Ling-xiang Xu, Ruyi Huang, Yu-Ying Ma et al. · 0 citations

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