Author

Yang Yang

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Review Open access Oct 2026

The gasdermin family: from pyroptosis mechanisms to therapeutic targets

The gasdermin (GSDM) family of proteins has emerged as the central executioner of pyroptosis, a form of inflammatory cell death characterized by plasma membrane rupture and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-18 and high mobility group protein B1 (HMGB1). Emerging evidence indic...

Weilv Xu, Shi-Yang Liu, Ze-Xu Yu et al. · Signal Transduction and Targ... · 0 citations

Open access Sep 2026

EspF acts as a molecular scaffold to facilitate TRIM25-mediated NLRP3 inflammasome activation during mycobacterial infection

EspF-TRIM25-NLRP3 axis is a novel mechanism of mycobacterial pathogenesis that drives hyperinflammation to facilitate bacterial survival and dissemination.

Yang Yang, Yi-Xin Han, Long-Jian Wu et al. · Virulence · 0 citations