Author

Yang-Yang Gong

2 papers indexed here

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Open access Sep 2026

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

ABSTRACT Pancreatic adenocarcinoma (PAAD) is an immunosuppressive malignancy refractory to radiotherapy and immunotherapy. Conventional tumor vaccines fail in PAAD due to a suppressive tumor microenvironment (TME), inadequate antigen presentation, and impaired immunogenic cell death (ICD). Using a machine learning‐driv...

Cheng-Yi Huang, Yu-Shu Han, Xiang Liu et al. · Advancement of science · 0 citations

Sep 2026

GSH-responsive nanoparticle drug delivery system for simultaneous blockade of CD73/A2AR to reverse adenosine-mediated immunosuppression.

The adenosine signaling pathway is a key mechanism of tumor immune evasion, collaboratively promoting immunosuppression through CD73-mediated adenosine production and A2AR-mediated signal transduction. This study designed and synthesized two novel conjugates, BSC and BSPC, which chemically link the CD73 inhibitor betul...

Chuan-Hao Wang, Yang-Yang Gong, Dao-Zuan Zhang et al. · Biomaterials Advances · 0 citations