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Yang-Yang Tao

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Review Open access Oct 2026

Exploring the potential role of PD-L2 in primary melanoma immunotherapy resistance: a hypothesis-driven dual-ligand framework

The treatment of melanoma has been significantly improved by immune checkpoint blockade (ICB); however, primary immune resistance, particularly in PD-L1-negative tumors and in selected treatment contexts, remains a critical efficacy bottleneck. Traditional biomarkers show clear limitations in explaining resistance...

Wen-Jing Song, Yang-Yang Tao, Xiang Ji et al. · 0 citations

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