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Yang-Yang Xu

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Open access Oct 2026

Urinary cell TWIST1 methylation as a non-invasive dual biomarker: A Multicenter study for early detection and recurrence monitoring in bladder cancer.

OBJECTIVE To develop and validate a non-invasive urine-based TWIST1 methylation-specific quantitative methylation‑specific polymerase chain reaction (qMSP) assay for bladder cancer (BC) diagnosis and surveillance to address the clinical need for a reliable complement invasive cystoscopy. METHODS This multicenter stud...

Yue Li, Xiang-Dong Li, Li-Juan Jiang et al. · 0 citations
Aug 2026

Targeted Degradation of ATP7B via a Novel Autophagy-Targeting Chimera Promotes Cuproptosis to Potentiate Anti-Tumor Immunity in Clear Cell Renal Cell Carcinoma.

The RNF186-p62-ATP7B axis is identified as a critical regulator of copper homeostasis in ccRCC and Targeting ATP7B via ATAUTAC offers a potent strategy to induce cuproptosis and sensitize ccRCC to immunotherapy.

Muyang Cao, Zhenkun Dong, Yang-Yang Xu et al. · 0 citations

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