Open access
Aug 2026
A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function
The extent to which JAK/STAT cytokine signaling is functionally redundant or selective remains debated. Here we engineered a “double” orthogonal IL-2/IL-2Rβ/γc ternary system enabling programmable, interference-free activation of each of the 36 mammalian cytokine receptors, and their downstream six STATs, in T cells. A...
Pingdong Tao, Ruchir Rastogi, Hua Jiang et al.
· bioRxiv · 0 citations