Sep 2026
Hematopoietic HCAR2 attenuates atherosclerosis by enhancing efferocytosis via AMPK/ABCA1 signaling.
BACKGROUND Atherosclerotic plaque progression involves lipid accumulation, inflammation, and impaired efferocytosis, the macrophage mediated clearance of apoptotic cells. HCAR2, a metabolite sensing receptor highly expressed on macrophages, modulates immune metabolic responses, but its role in efferocytosis and atheros...
Jia-Cheng Chen, Li Jiang, Feng-Ying Zhang et al.
· International Immunopharmaco... · 0 citations