Yang Zhou

Metformin Alleviates High Glucose-Induced Pyroptosis and Inflammatory Responses in HK-2 Cells via SIRT1-Associated Regulation of the TXNIP/NLRP3 Pathway.

BACKGROUND Diabetic kidney disease (DKD) is a major cause of renal failure and end-stage renal disease. Pyroptosis, a Gasdermin-dependent inflammatory form of programmed cell death, has been implicated in DKD progression. Metformin has shown renoprotective effects in DKD; however, the underlying mechanisms remain uncle...