Industrial phenolic compounds targeting 11β-hydroxysteroid dehydrogenase 2: A comparative in silico and structure-activity investigation in humans and rats.
Industrial phenolic compounds (IPCs) are widespread environmental contaminants with known endocrine-disrupting potential. This study aimed to investigate the inhibition of 13 IPCs on human and rat 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), a crucial enzyme responsible for cortisol inactivation. The inhibitory poten...