Open access
Aug 2026
MFN2 inhibits colorectal cancer tumorigenesis by regulating glycolysis through TRIM21-mediated PFKP stability.
Overexpression of MFN2 suppressed CRC cell glycolysis and tumor growth by enhancing TRIM21-mediated degradation of PFKP andilitation of TRIM21 to PFKP to mediate its degradation, thereby hindering the malignant progression of CRC.
Huiyuan Jiang, Hongwei Guo, Yan Wang et al.
· Molecular Immunology · 0 citations