Author

Yao He

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Open access Sep 2026

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

This study identified pericytes as novel fibrotic effector cells in IVDD, contributing to fibrosis through activation of the TGF‐β signaling pathway, and developed a microgel platform designed to specifically inhibit pericyte activation and pro‐fibrotic transition.

Fei Ma, Zhen Zhao, Chuan Guo et al. · Advancement of science · 0 citations

Open access Sep 2026

A dual-targeted oligonucleotide delivery hydrogel for diabetic wound healing: Regulating macrophage-endothelial crosstalk and ferroptosis.

It is demonstrated that this integrated system precisely remodels the pathological immune microenvironment, establishing a promising oligonucleotide-based therapeutic strategy for clinical diabetic wound regeneration.

Mei Zhang, Wen-Bin Yang, Xiao Fu et al. · Journal of Controlled Releas... · 0 citations

Jul 2026

An Enzyme‐Responsive Nucleic Acid‐Based Nanoassembly for Coordinated Co‐Delivery of microRNA and Puerarin in Osteoporotic Bone Regeneration

This work elucidates a synergistic therapeutic strategy that integrates genetic and small‐molecule drugs via nucleic acid nanostructure reengineering, providing foundations for developing next‐generation dynamic nanomaterials for recalcitrant tissue defects.

Yuxuan Zhao, Kai-Wen Zhang, Xin-Man Mo et al. · Advanced Functional Material... · 1 citation