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Author

Yao-Hui Shi

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Aug 2026

MitoGPS: A Mitochondrial DNA G-Quadruplex-Targeting Strategy for Tumor-Preferential Type I Photodynamic Therapy.

Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off-target toxicity. Here, we introduce the mitoGPS (mitochond...

Yu-Hui Guo, Yao-Hui Shi, Pei-Min Huang et al. · 0 citations
Aug 2026

Discovery and Biosynthesis of Brasilanes G−L: N -Acetylglucosamine-Decorated Sesquiterpenoids with Anti-Inflammatory Activity

N-Acetylglucosamine (GlcNAc)-decorated natural products represent a structurally unique class of metabolites that possess diverse biological activities. Through the genome mining of Coccidioides sp. CMB-TN39F, we identified a GlcNAc transferase-encoding terpene synthase gene cluster brc. Heterologous expression of th...

Ming-Min Wu, Yao-Hui Shi, Yu-Wei Lin et al. · 0 citations

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