MitoGPS: A Mitochondrial DNA G-Quadruplex-Targeting Strategy for Tumor-Preferential Type I Photodynamic Therapy.
Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off-target toxicity. Here, we introduce the mitoGPS (mitochond...