Neuronal progranulin in the medial prefrontal cortex mediates stress-induced despair-like behaviors and impaired neuroplasticity.
BACKGROUND Neuroplasticity in the medial prefrontal cortex (mPFC) is critically implicated in major depressive disorder (MDD). Progranulin (PGRN), a multifunctional protein that is abundant in the cortex, regulates neuronal development and synaptic maintenance, positioning it as a candidate therapeutic target for MDD....