Author

Yasaman Kargar Gaz Kooh

2 papers indexed here

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Open access Sep 2026

Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM

Hypertrophic cardiomyopathy (HCM) is commonly caused by pathogenic variants in the sarcomere, such as truncations in myosin-binding protein C (MYBPC3), yet clinical severity and adverse outcomes correlate poorly with genotype alone and are strongly influenced by fibrosis. We developed an engineered human micro-heart ti...

Huan-Zhu Jiang, Ganesh Malayath, Nongmaithem Debeni Devi et al. · APL Bioengineering · 0 citations

Open access Aug 2026

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

Background: Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiomyocytes. Mutations in PQC pathway proteins, namely CRYAB-R120G (arginine to glycine at position 120) and BAG3-P209L (proline to lysine at position 209) induce protein aggregates and cardiomyopathy in humans....

David R. Rawnsley, Moydul Islam, Chen Zhao et al. · Circulation Research · 0 citations