Open access
Jul 2026
Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells
It is shown that CRC cells transiently adopt a wound-healing program normally used by epidermal keratinocytes during tissue repair to enable metastatic dissemination, and this state is reversible, as cells reacquire primary tumor–like characteristics upon colonization of distant organs.
M. Sakahara, Takuya Okamoto, Kohei Kumegawa et al.
· Nature Communications · 0 citations