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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Yaxi Du

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Open access Sep 2026

A Lynch Syndrome Family With Germline MLH1 c.931A>G Showing Preserved Tumor MMR Immunostaining but MSI‐H Status: A Case Report

This case highlights that preserved tumor MMR immunostaining does not exclude Lynch syndrome when clinical suspicion is high and Concurrent MSI and MMR immunohistochemistry, interpreted together with tumor sequencing and germline testing, may improve diagnosis, treatment selection, and familial risk assessment.

Jing-Jing Cai, Zhuo-Ying Li, Ting-Ting Han et al. · 0 citations
Aug 2026

ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.

ACOD1 is highly expressed in TNBC TAMs and is driven by TME signals, independent of the classical M2 polarization pathway, and promotes ITA binding to KEAP1, which inhibits the KEAP1-NRF2 interaction and thus activates NRF2-mediated antioxidant and ferroptosis resistance responses in TAMs, promoting TNBC progression.

Jie Yang, Xiyin Li, Xin Qu et al. · 1 citation

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