Yee-Hsee Hsieh

Co-injections of L-NAC methyl ester reduce the loss of antinociception and prevent the occurrence of hyperalgesia elicited by injections of fentanyl in male rats.

The development of hyperalgesia (i.e., enhanced physical pain and/or psychological distress) during chronic fentanyl use plays a vital role in the continued and accelerated use of this potent synthetic opioid. Numerous biochemical changes in the brain, such as changes in redox status, are thought to contribute to the d...