Cryptococcus neoformans is a major fungal pathogen with severely limited therapeutic options. We evaluated the antifungal activity of the lipopeptide iturin A against eight clinical isolates of C. neoformans. Iturin A exhibited robust anti-cryptococcal activity, with minimum inhibitory concentrations ranging from 12.5...
Yehia Elgammal, Rafael García-Martínez, C. Charles-Niño et al.· npj Fungal Science· 0 citations
Candida auris is an emerging multidrug-resistant fungal pathogen and a major global health threat, highlighting the urgent need for new therapeutics. We screened ~2,600 FDA-approved drugs and clinical compounds and identified darapladib (DAL), a phospholipase A2 inhibitor, as a potent antifungal agent against multidrug...
Yehia Elgammal, Ehab A. Salama, Nour M. Alkashef et al.· PLoS ONE· 0 citations
Abstract Candidozyma auris has emerged as one of the most formidable fungal pathogens of the modern era, designated a critical priority pathogen by the World Health Organization due to its multidrug resistance, thermotolerance, and capacity to cause prolonged outbreaks in healthcare settings. Unlike most fungal pathoge...
Débora Silva Marques de Sousa, Ana Karla Lima Freire Cabral, Bruno Bulgarelli Adorno Arantes et al.· Critical reviews in microbio...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.