Longitudinal CDR-Sum of Boxes trajectories in mild cognitive impairment reveal functional heterogeneity beyond cognitive decline: A latent class growth analysis
Background Mild cognitive impairment (MCI) is clinically heterogeneous, yet most prognostic studies rely on binary conversion endpoints or expensive biomarkers unavailable in routine practice. Objective To identify trajectory classes of the Clinical Dementia Rating-Sum of Boxes (CDR-SB) progression in MCI using latent...