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Open access Aug 2026

Surface-engineered milk-derived extracellular vesicles enable oral miRNA therapy against immunosuppressive pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) shows limited responsiveness to conventional therapies due to an immunosuppressive tumor microenvironment (TME) characterized by programmed death-ligand 1 (PD-L1)-mediated immune escape and oncogenic microRNA-21 (miR-21) signaling. Despite the potential of miRNA therapeutics, the...

Youngri Ryu, Hochung Jang, Eun Hye Kim et al. · 0 citations
Open access Jul 2026

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and seve...

Eun-Hae Jang, E. Yang, Gil Song et al. · 0 citations

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